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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NR1I2 All Species: 8.48
Human Site: S305 Identified Species: 20.74
UniProt: O75469 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75469 NP_003880.3 434 49762 S305 T W E C G R L S Y C L E D T A
Chimpanzee Pan troglodytes A2T7D9 348 39540 Q235 D G A R V G F Q V E F L E L L
Rhesus Macaque Macaca mulatta Q8SQ01 434 49974 S305 T W E C G R L S Y C L E D P A
Dog Lupus familis XP_535750 898 98286 S769 T W E C G R L S Y C L E D P A
Cat Felis silvestris
Mouse Mus musculus O54915 431 49549 A302 T W E C G R L A Y C F E D P N
Rat Rattus norvegicus Q9R1A7 431 49642 A302 T W E C G R L A Y C F E D P N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O42392 451 51281 D316 S W T C G S N D F K Y K V S D
Frog Xenopus laevis O13124 422 48170 D287 S W T C G S E D F K Y K V D D
Zebra Danio Brachydanio rerio Q1L673 422 47645 E289 S W S C G G P E F K Y C V N D
Tiger Blowfish Takifugu rubipres Q9W5Z3 447 49514 L284 T F S D G L T L N R T Q M H N
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.3 95.3 40 N.A. 76.7 76.2 N.A. N.A. 39.9 41 42.6 23.2 N.A. N.A. N.A. N.A.
Protein Similarity: 100 54.6 97.6 43.9 N.A. 86.1 85.7 N.A. N.A. 58.3 58.7 59.2 38 N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 93.3 93.3 N.A. 73.3 73.3 N.A. N.A. 20 20 20 13.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 6.6 93.3 93.3 N.A. 80 80 N.A. N.A. 46.6 40 33.3 26.6 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 20 0 0 0 0 0 0 30 % A
% Cys: 0 0 0 80 0 0 0 0 0 50 0 10 0 0 0 % C
% Asp: 10 0 0 10 0 0 0 20 0 0 0 0 50 10 30 % D
% Glu: 0 0 50 0 0 0 10 10 0 10 0 50 10 0 0 % E
% Phe: 0 10 0 0 0 0 10 0 30 0 30 0 0 0 0 % F
% Gly: 0 10 0 0 90 20 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 30 0 20 0 0 0 % K
% Leu: 0 0 0 0 0 10 50 10 0 0 30 10 0 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 10 0 10 0 0 0 0 10 30 % N
% Pro: 0 0 0 0 0 0 10 0 0 0 0 0 0 40 0 % P
% Gln: 0 0 0 0 0 0 0 10 0 0 0 10 0 0 0 % Q
% Arg: 0 0 0 10 0 50 0 0 0 10 0 0 0 0 0 % R
% Ser: 30 0 20 0 0 20 0 30 0 0 0 0 0 10 0 % S
% Thr: 60 0 20 0 0 0 10 0 0 0 10 0 0 10 0 % T
% Val: 0 0 0 0 10 0 0 0 10 0 0 0 30 0 0 % V
% Trp: 0 80 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 50 0 30 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _